Journal Name:
- The International Journal of Pharmaceutical Research and Bio-Science
Abstract (2. Language):
The aim of present study was to design the concept of bilayer matrix tablets containing Acarbose as immediate release component using sodium starch glycolate and cross carmillose sodium as super disintegrates and Metformin hydrochloride (HCl) for sustained release by using hydroxyl propyl methyl cellulose (HPMC K 4M), (HPMC K 100) and sodium carboxyl methyl cellulose (SCMC) as the matrix forming polymer and PVPK-30 as binder. Matrix tablet are the type of controlled drug delivery systems, which release the drug in continuous manner. These release the drug by both dissolution controlled as well as diffusion controlled mechanisms the half life of metformin HCl is 6.2 hrs, so an attempt was made in the direction of preparation and optimization of a combination of sustained release and immediate release in a single tablet. Tablets were prepared by wet granulation and direct compression method. Tablets were evaluated for post compression parameters. The tablets were evaluated for physico-chemical property. All the values were found to be satisfactory. Invitro release studies were carried as per USP in water and phosphate buffer of pH 6.8 using the apparatus I. The final preparation showed release of drug up to 96.75 in 8 hours. FTIR studies revealed that there is no interaction between the drug and other excipients used in the study.
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FULL TEXT (PDF):
- 6
123-139