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Memelilerde Ortalama Yaşam Süresi ve Yaşlanma Sürecinde Serbest Radikallerin Rolü

The role of free radicals in the aging process and average life span in mammals

Journal Name:

  • İstanbul Üniversitesi Veteriner Fakültesi Dergisi

Publication Year:

  • 2007

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Serbest oksijen radikalleri yaşlılığın önemli nedensel ajanlarıolarak kabul edilmektedirler. Bu derlemede, antioksidan korunma ve yaşam süresi arasındaki ilişki, oksidatif hasardaki azalmanın yaşam süresine etkisi ve serbest radikal hasarıile yaşlanmada beslenmenin etkileri konularıirdelenmiştir. Serbest radikallerin ana kaynağımoleküler oksijendir. Moleküler oksijenin tek valanslıredüksiyonu (univalent redüksiyonu) süperoksit dismütaz anyonları(O2 .-) hidrojen peroksit (H2O2) ve hidroksil radikalleri ( . OH) gibi reaktif oksijen türlerini oluşturur. Sitotoksik türler hücrede oksidatif hasara neden olabilir. Nitekim yaşlılık bu oksidatif değişikliklerin birikimi ile ilgili geri dönüşümsüz hasarların bir işleyişi olarak düşünülebilir. Yaşlanma olayında antioksidan enzim aktivitelerinin arttığıya da azaldığıbelirtilmektedir. Birçok araştırmaya göre yaşlıdokularda yaşlanma sırasında yüksek oranlarda üretilebilen serbest radikallere karşıetkili bir antioksidan savunma sağlayan bazıdüzenleyici mekanizmalar vardır. Yaşlılığın primer nedeninin okside moleküller olduğu hakkında kesin delil yoktur. Yaşlanma muhtemelen çok yönlü bir olaydır ve herhangi bir tek nedene indirgenemez.
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Abstract (Original Language): 
Free oxygen radicals have been proposed as important causative agents of aging. In this review, the relationship between antioxidant protection and life span, the effects of reduced oxidative damage on the life span and the effects of dietary manipulationson ageing and free radical damage were discussed. The main source of the free radicals is molecular oxygen. The univalent reduction of molecular oxygen results in reactive oxygen species (ROS) such as superoxide dismutase anions (O2 .-), hydrogen peroxide (H2O2) and hydroxyl radicals ( . OH). The cytotoxic species can cause oxidative damage in the cell. Aging can thus be viewed as a process of irreversibleinjuries associated with accumulation of these oxidative changes. Activity of antioxidant enzymes has been reported to either increase or decrease in the aging process. According to many studies there are some regulatory mechanisms in senescent tissues to provide an efficient antioxidant defence against free radicals, which may be generated ata higher rate during the aging process. Definitive proof that oxidised molecules are the primary cause ofageing is lacking. Aging is also likely to be a multifactorial process and not reducible to any one single cause.
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  • Turkish

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