Buradasınız

Anasayfa » Content

Çok düşük (50 Hzj frekanslı manyetik alanın farelerin serum kortizol ve testosteron düzeyleri ile testis histolojisi üzerindeki etkilerinin belirlenmesi

Effects of extremely low frequency [50 Hz) magnetic field on serum Cortisol and testosterone levels and testes histology of the mice

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Aim: Since public exposure to extremely low frequency [50 Hz] magnetic fields [ELF-MF) is gradually increasing in industrialized countries, research efforts have focused on the possible effects of the ELF-MF fields on the human health. In this study, it was aimed to find out the effects of ELF-MF at various intensities on serum Cortisol and testosterone levels and to determine histological changes in the testes of the ELF-MF-exposed mice. Material and method: Sixty four mice (Swiss albino mice) obtained from Selçuk University Experimental Medicine Research and Application Center were used in the sudy. The experimental groups were exposed to 50 Hz MF at different intensities [10, 30 and 50 mG) for 40 days. Results: The serum Cortisol levels of the male mice decreased by field effect but in female mice no significant differences were found between control and expo¬sure groups. However, the differences between the control and exposure groups were not significant when the serum Cortisol levels of male and female mice were regarded as a wholes. Serum testosterone level of the 50 mG group was significantly higher than those of the other groups. No significant histological changes were determined in the testes in both control and any exposure groups. Conclusion: There is no direct correlation between the ELF-MF intensity and serum Cortisol and testosterone levels, and ELF-MF does not cause histologi¬cal changes in testes.
Bookmark/Search this post with
Abstract (Original Language): 
Anaç: Endüstriyel ülkelerde, 50 Hz'lik çok düşük frekanslı manyetik aianiara (ÇDF-MAJ giderek daha fazla maruz kalındığından, bu alanların insan sağlığı üzerindeki olumsuz etkilerinin belirlenmesine yönelik araştırmalar yoğunluk kazanmıştır. Bu çalışmada, farelerde farklı şiddetlerdeki ÇDF-MA'nın serum kortizol ve testosteron düzeylerine etkisinin ve testislerde oluşan histolojik değişikliklerin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmada Selçuk Üniversitesi Deneysel Tıp Araştırma ve Uygulama Merkezinden temin edilen 64 fındık faresi {Swiss albino fare) kullanıldı. Uygulama gruplarındaki hayvanlar 40 gün süreyle 50 Hz'lik farklı şiddetlerdeki (10, 30 ve 50 mGJ manyetik alana maruz bırakıldı. Bulgular: Erkek farelerin serum kortizol düzeyleri alan etkisiyle önemli derece düşerken, dişilerin serum kortizol düzeyleri etkilenmedi. Erkek ve dişi farelerin serum kortizol düzeyleri birlikte değerlendirildiğinde, gruplar arasında fark yoktu. Serum testosteron düzeyleri, 50 mG manyetik alana maruz bırakılan erkek hayvanlarda diğer gruplardakinden önemli derecede yüksekti. Hem kontrol grubun¬da hem de çalışma gruplarında testislerde önemli bir histolojik değişikliğe rastlanmadı. Sonuç: Farelerin farklı şiddetlerdeki ÇDF-MA'na maruz bırakılmasıyla serum kortizol ve testosteron düzeyleri arasında doğrusal bir ilişkinin bulunmadığı ve testislerde histolojik değişiklik oluşmadığı sonucuna varıldı.
FULL TEXT (PDF): 
PDF icon arastirmax-cok-dusuk-50-hzj-frekansli-manyetik-alanin-farelerin-serum-kortizol-testosteron-duzeyleri-ile-testis-histolojisi-uzerindeki-etkilerinin-belirlenmesi.pdf
  • 1
1-7
  • Turkish

REFERENCES

References: 

1. Wertheimer N, Leeper ED. Electrical wiring configura¬tions and childhood cancer. Am J Epidemiol 1979; 109:273-84.
2. Wertheimer N, Leeper ED. Adult cancer related to elec¬trical wires near the home. IntJ Epidemiol 1982;! 1:345¬55.
3. Tomenius L. 50 Hz electromagnetic environment and incidence of childhood tumours in Stockholm Country. Bioelectromagnetics 1986; 7:191-207.
4. Feycnting M, Ahlbom A. Magnetic fields and cancer in children residing near Swedish high-voltage power lines. Am J Epidemiol 1993; 138:467-81.
5. Floderus B. Persson T, Stenlud C. Increased risk of leukemias and brain tumors in occupational exposure to magnetic fields. Lakartidningen 1992; 89:4363-6.
6. Tynes T, Andersen A. Electromagnetic fields and male breast cancer. Lancet 1990; 336: 1596.
7. Barnes FS. Typical electric and magnetic field exposures at power-line frequences and their coupling to biological systems. In: "Electromagnetic fields. Biological interac¬tions and mechanisms." Ed. Blank M., American Chemical Society, Washington. DC; 1995, 37-55.
8. Salbacak A, Karabulut AK. Çelik i. Soylu R. Manyetik Alanların Memeli EmbriyogeneziSİ Üzerine Etkileri: İn Vitro Kültürü Yapılan Rat Embriyolarında Morfolojik ve Histololojik Araştırmalar. S.Ü. Bilimsel Araştırma Projeleri Koordinatörlüğü, 2002 Proje No: TF- 99/133.
9. Lee JS, Ahn SS, Jung KC, Kim YW. Lee SK. Effects of 60 Hz electromagnetic field exposure on testicular germ cell apoptosis in mice. Asian J Androl 2004; 6:29-34.
10. Margonato V, Veicsteinas A Conti R, Nicolini P. Cerretelli P. Biologic effects of prolonged exposure to ELF electro¬magnetic fields in rats. I. 50 Hz electric fields. Bioelectromagnetics 1 993; 1 4:479-93.
11. Mann K, Wagner P. Brunn G, Hassan F, Hiemke C, Roschke J. Effects of pulsed high-frequency electromag¬netic fields on the neuroendocrine system. Neuroendocrinology 1998; 67:139-44.
12. Gamberale F, Olson BA. Eneroth P. Undh T, Wennberg A. Acute effects of ELF electromagnetic fields: a field study of linesmen working with 400 kV power lines. Br J IndMed 1989; 46,10.729-37.
13. Arnetz BB. Berg M. Melatonin and adrenocorticotropic hormone levels in video display unit workers during work and leisure. J Occup Environ Med 1996; 38:1 108-10.
14. Culling CFA Allison RT. Barr WT. Cellular Pathology Technique, London: Butterworths and Co Ltd; 1 985.
1 5. üvingston GK, Witt KL, Gandhi OP, Chatterjee I. Roti JL. Reproductive integrity of mammalian cells exposed to power frequency electromagnetic fields. Environ Mol Mutagen 1991; 17:49-58.
16. Wachtel H. Firing-pattern changes and transmembrane currents produced by extremely low frequency fields in pacemaker neuron. NTIS Document No. CONF-781016:132-146 Hanford Life Sciences Symposium, I 8th Annual Meeting. (1979) 16-18 October, 1978, Richland, WA.
17. Carlsen E, Giwercman A, Keiding N. Skakkebaek Nt. Declining semen quality and increasing incidence of tes¬ticular cancer: is there a common cause? Environ Health Perspect 1995; 103 Suppl 7:137-9.
18. Irgens A, Kruger K. Ulstein M. The effect of male occupa¬tional exposure in infertile couples in Norway. J Occup Environ Med i 999; 41:111 6-20.
1 9. Lundsberg LS, Bracken MB, Belanger K. Occupaiionally related magnetic field exposure and male subfertility. Fertil Steril 1995; 63:384-91.
20. Niehaus M, Bruggemeyer H. Behre HM Lerchl A. Growth retardation, testicular stimulation, and increased melatonin synthesis by weak magnetic fields (50 Hz) in Djungarian hamsters, Phodopus sungorus. Biochem Biophys Res Commun 1997; 234: 707-1 I.
21. Ryan BM, Symanski RR, Pomeranz LE, Johnson TR. Gauger JR. McCormic DL. Multigeneration reproductive toxicity assessment of 60-Hz magnetic fields using a con¬tinuous breeding protocol in rats. Teratology 1999; 59:156-62.
22. Al-Akhras M, Elbetieha A, Hasan M, Al-Omari I, Darmani H, Albiss B. Effects of extremely low frequency magnetics field on fertility of adult male and female fats. Bioelectromagnetics 2001; 22:340^i.
23. De vita R, Cavailo L. Raganela P. Eleuteri MG, Grollino MG. Calugi A. Effects of 50 Hz magnetic fields on mouse spermatogenesis monitored by flow cytometric analysis. Bioelectromagnetics 1995; 16:330-4.
24. Elbetieha A, Al-Akhras M, Darmani H. Long-Term Exposure of male and female mice to 50 Hz magnetic field effects on fertility. Bioelectromagnetics 2002; 23:168-72.
25. Emura R, Ashida N, Higashi T, Takeuchi T. Orientation of bull sperms in static magnetic fields. Bioelectromagnetics 2001; 22:60-5.
26. Ghaiy M. And Teplitz D. The biological effects of grounding the human body during sleep as measured by Cortisol levels and subjective reporting of sleep, pain and stress. J Altern Complement Med. 2004; 10:767-76.
27. Goodman R, Blank M. Biosynthetic stress response in cells exposed to electromagnetic fields. "Electromagnetic fields. Biological interactions and mechanisms" Ed. Blank M„ Washington, DC: American Chemical Society; 1995; 3423-36.

Çok düşük frekanslı manyetik alanın serum kortizoi ve testosteron düzeyleriyle test/s histolojisi üzerine etkileri

28. Greene ±1. Skowronski WJ, Mullins JM, Nardone RM, Penafiel M. Meister R. Delineation of electric and mag¬netic field effects of extremely low frequency electro¬magnetic radiation on transcription. Biochem Biophys Res Commun 1991; 174:742-9.
29. Blank M, Soo L. The Na/K-ATPase as a model for electro¬magnetic field effects on cells. Bioelectrochem Bioenerg 1993; 30:85-92.
30. Murthy MS. Liquid crystallinity in collagen solutions and magnetic orientation of collagen fibrils. Biopolymers 1984; 23:1261-7.

31. Hinsenkamp M, Lheureux P, Mortins D. Transmembrase Na/K exchange under electromagnetics fields. Reconstr SurgTraumat 1985; 19:63-9.
32. Bardasano JL, Meyer AJ, Picazo L. Pineal cells with multi¬polar spindles in chicken embryos exposed to magnetic fields-first trials. Z Mikrosk Anat Forsch 1986; 100: 85-92.

Thank you for copying data from http://www.arastirmax.com