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Hemodiyaliz Hastalarında Hemostatik Sistemin Arteriyovenöz Fistül Trombozu Yönünden İncelenmesi

Evaluatıon of Hemostatic System in Patients with Arteriovenous Fistula Thrombosis on Hemodialysis

Journal Name:

  • Selçuk Tıp Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Hemodialysis patients have a tendency toward to thrombosis. AVF thrombosis is frequent in those patients. Study was aimed to evaluate patients by means of hemostatic state at our study, hemostatic parameters in haemodialysis patients with respect to healthy group were evaluated. Haemodialysis group (HDG) consisted of 45 patients (27 male, 18 female) and control group (CG) consisted of 15 healthy persons (8 male, 7 female). These parameters were evaluated whether contributing to thrombosis APC resistance is found to be higher in patient group. AT III and tPA antigen levels are low in patient group, while vWF antigen levels are high in patients with AVF problem compared to healthy subjects. Hypofibrinolysis and prethrombotic state were thought to play role in contributing vascular endothelial injury and AVF thrombosis. These findings reflect the pre-trhrombotic state and injured vascular endothelium in HDG with AVF problems. Thus, Hemodialysis patients must be screened and evaluated by means of pre-thrombotic events for better AVF survival and outcome.
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Abstract (Original Language): 
Hemodiyalize giren hastalarda trombotik yöne doğru eğilim artmıştır. Bu nedenle bu hastaların hemostatik durum yönünden araştırılması planlanmıştır. Araştırma için hemodiyalize giren 45 hasta ile (27 erkek, 18 kadın) 15 sağlıklı kontrol grubu (8 erkek, 7 kadın) hemostatik parametreler açısından karşılaştırıldı. Hemodiyaliz hastalarında APC rezistansı ve rezistans oranının yüksek olduğu, AT- III ve tPA antijen düzeylerinin düşük olduğu saptandı. AVF trombozu olan vakalarda tromboz öyküsü olmayan AVF hastalarına göre anlamlı bir şekilde vWF antijen seviyelerinin yüksek olduğu saptandı. Hemodiyalize giren hastalarda APC rezistansının yüksek olduğunu, bu yüksekliğin pre-trombotik duruma yardımcı olabileceğini, AT III düşüklüğünün de yine pre-trombotik durum yönünden etkiyebileceğini, tPA düşüklüğünün hipofibrinolizi yansıttığını ve bu yüzden pretrombotik durum olarak etki edebileceğini, AVF problemi olan hastalarda vWF yüksekliğinin bunlardaki vasküler endotel hasarının daha fazla olduğunu ve bunun da trombojenik bir faktör olarak pretrombotik duruma katkı edebileceğini gösterdi. Hemodiyalize giren hastalarda tormbotik AVF problemlerinde pre-trombotik durumların taranması ve araştırılması, AVF sağkalımı açısından önemli bir yaklaşımdır.
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  • 3
71-75
  • Turkish

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