Buradasınız

Anasayfa » Content

The Morphometric Effects of Testosterone, Used as a Doping Agent, on the Humerus and Femur of Pubescent Male and Female Rats

Journal Name:

  • Selçuk Üniversitesi Beden Eğitimi ve Spor Bilim Dergisi

Publication Year:

  • 2011

Key Words:

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of this study was to examine the morphometric effects of testosterone on some osteological structures in pubescent rats. For this purpose, 16 male and 16 female rats were allocated equally to control and experimental groups. After calculating the average weight of all rats, testosterone was administered at a dose of 5 mg/kg body weight (bw) by subcutaneous route, 5 days a week for 10 weeks. At the end of the 10th week, all the rats were euthanized; and corpus and height measurements of the femur and humerus, and cortex and cavum medulla morphometric measurements were made. A significant decrease was detected in the corpus femoris and height measurements of the male rats administered with testosterone (P<0.05). However, no significant difference was found for female rats (P>0.05). A significant decrease was determined in the corpus humeri and height measurements of female and male rats administered with testosterone (P<0.05). Statistically significant differences were determined between the femur-humerus and cortexcavum medulla measurements of the testosterone and control groups (p<0.05). In result, testosterone caused some morphometric changes in the extremity bones of pubescent rats included in the experimental group. A parallelism can be drawn between the results of this study and results derived from the use of anabolic-androgenic steroids by young athletes. The results of the present study may contribute to raising awareness among athletes on the adverse effects of anabolic-androgenic steroids.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-morphometric-effects-testosterone-used-doping-agent-humerus-and-femur-pubescent-male-and-female-rats.pdf
  • 13
172-176
  • English

REFERENCES

References: 

1. Ahlborg HG, Johnell, O, Turner CH, Rannevik G,
Karlsson MK. Bone Loss and Bone Size after
Menopause. N Engl J Med 2003; 349: 327-334
2. Alim A, Eliçevik M, Paşaoğlu E, Önal H, Söylet Y.
The effects of human chorionıc gonadaotropin and testosterone
on penis, testis, cerebrum, adrenal cortex and bone in
prepubertal rats. In:15. Pediatric surgery congress;
2007 Oct 22-27; Izmir, Turkey.p.58
3. Bahrke MS, Yesalis CE, Brower KJ. Anabolicandrogenic
steroid abuse and performance
enhancing drugs among adolescents. Child Adolesc
Psychiatr Clin N Am 1998; 7: 821-838
4. Behre HM, Kliesch S, Leifke E., Link TM. Nieschlag
E. Long-term effect of testosterone therapy on bone
mineral density in hypogonadal men. J Clin Endocrinol
Metab 1997; 82: 2386-2390.
5. Blystone CR, Furr J, Lambright CS, Howdeshell KL,
Bryce C, Ryan BC, et al. Prochloraz inhibits
testosterone production at dosages below those that
affect androgen-dependent organ weights or the
onset of puberty in the male Sprague Dawley rat.
Toxicol. Sci 2007; 97: 65-74
6. Bonnet N, Benhamou CL, Brunet-Imbault B,
Arlettaz A, Horcajada MN, Richard O, et al.
Courteix D: Severe bone alterations under β2
agonist treatments: Bone mass, microarchitecture
and strength analyses in female rats. J Bone 2005; 37:
622-633
7. Brower KJ. Anabolic steroids. Psychiatr Clin North
Am 1993; 16: 97-103
8. Eryarsoy-Turan FF. Medicine II.Serum androgen levels in
patients with diabetes mellitus. T.C. Ministry of Health.
Dr. Lütfi Kırdar Kartal Education and Research
Hospital Clinical Biochemistry Dissertation,
Istanbul, Turkey. 2006
9. Kayaalp O. Medical Pharmacology with the aspect of
rational treatment. 10 th. ed. Ankara: Feryal Press;
2002: p. 1014
10. Kitaura T, Tsunekawa N, Kraemer WJ. Inhibited
longitudinal growth of bones in young male rats by
clenbuterol. Med Sci Sports Exerc 2002; 34: 267-273
11. Lök S. The morphometric effect of nandrolone, used as a
doping agent in sports, on the femur and humerus of rats in
puberty. Konya .S.U. Institute of Health Sciences.
doctorate thesis 2009; p. 26-54
12. McDougall KE, Perry MJ, Gibson RL, Bright JM,
Colley SM, Hodgin JB, et al. Estrogen-induced
osteogenesis in intact female mice lacking ERβ. Am
J Physiol Endocrinol Metab 2002; 283: 817-823
13. NAV. Nomina Anatomica Veterinaria, International
Committee on Veterinary Gross Anatomical Nomenclature.
5th ed, Pub. by the Ed. Com.Hannover, Columbia,
Gent, Sapparo, USA; 2005
14. Nikon V-12. Emerg Infect Dis [serial online] Junel
2003 [cited 2009 Junel 4]. Available from URL
http://www.html.oml.gov/ mituc/nikon.htm
15. Özdemir E, Gültürk S. Anabolic-androgenic steroids
and physiological responses. Turk Clin J Med Sci
2008; 28: 923-932
16. Pope HG, Katz DL. Affective and psychotic
symptoms associated with anabolic steroid use. Am J
Psychiatry 1988; 145: 487-490
17. Pope HG, Katz DL. Psychiatric and medical effect
of anabolic-androgenic steroid use, a controlled
study of 160 athletes. Arch Gen Psyhiatry 1994; 51:
375-382
18. Pope HG, Brower KJ. Anabolic-androgenic Steroid
Abuse. In: BJ Sadock, VA Sadock, Kaplan, Sadock’s
Editors, Comprehensive Textbook of Psychiatry, 7.
Printing, Philadelphia Lippincott Williams and
Wilkins 2000; 1085-1095
19. Sevin G, Arun MZ. Üstünel L: Androgens and
Anabolic Steroids. T Clin J Int Med Sci 2005; 1: 78-89
20. Sims NA, Dupont S, Krust A, Clement-Lacroix P,
Minet D, Resche-Rigon M, et al. Castrated men
exhibit bone loss; effect of calcitonin treatment on
biochemical indices of bone remodelling. J Clin
Endocrinol Metab 2002; 69: 523-527
21. Tapp E. The effect of hormones on bone in growing
rats. J Bone Joint Surg BR 1966; 48: 3
22. Tramontana J, Benghuzzi H, Tucci M, Tsao A,
Hughes J. Morphometric analysis of cortical bone
upon the exposure to sustained delivery of anabolic
promoting agents adult male rats as a model. Biomed
Sci Insrum 2001; 37: 293-298
23. Turner RT, Wakley KG, Hannon KS. Differential
effect of androgens on cortical bone
histomorphometry in gonadectomized male and
female rats. J Orhtop Res 1990; 8: 612-617
24. Vardar E, Vardar SA, Cengiz T. Misuse of anabolicandrogenic
steroids. Anatolian Journal of Psychiatry
2002; 3: 104-107
25. Vardar E, Kurt C, Vardar SA. Usage of anabolic
androgenic steroids and ephedrine among athletes.
Society for the Study of Addiction 2004; 5: 20-23
26. Venken K, Skrtic SM, Kopchick JJ, Coschigano KT,
Ohlsson C, Boonen S, et al. Impact of androgens,
growth hormone and IGF-I on bone and muscle in
male mice during puberty. J Bone Miner Res 2007; 22:
72-82
27. Windahl SH, Vidal O, Andersson G, Gustafsson JA,
Ohlsson C. Increased cortical bone mineral content
but unchanged trabecular bone mineral density in
female ERβ mice. J Clin Invest 1999; 104: 895-901

Thank you for copying data from http://www.arastirmax.com