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Başarılı Böbrek Nakli Sonrası Otozomal Dominant Polikistik Böbrek Hastalarında Arteriyel Sertliğin Değerlendirilmesi

Evaluation of Arterial Stiffness after Successful Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease

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DOI: 
DOI 10.5262/tndt.2012.1003.14

Keywords (Original Language):

Abstract (2. Language): 
OBJECTIVE: Cardiovascular problems are a major cause of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). Our knowledge about cardiovascular events after renal transplantation in ADPKD patients are limited. This study aimed to compare arterial stiffness and cardiovascular risks in renal transplant recipients (RTRs) with and without ADPKD. MATERIAL and METHODS: 29 control patients with normal coronary angiography, 22 RTRs without ADPKD and 12 RTRs with ADPKD were studied. Arterial elasticity was determined by applanation tonometry in all participants. RESULTS: Age, height, weight, waist measurement, small artery elasticity index(SAEI) and fasting blood glucose were signifi cantly lower in patients with a kidney transplant (n=34) than in control subjects. Duration of dialysis before transplantation, family history of coronary artery disease, and mean age were signifi cantly higher in ADPKD compared to non ADPKD transplant patients. Arterial elasticity measurements (SAEI, LAEI) were the same in the two groups. CONCLUSION: SAEI levels were significantly lower in RTRs compared with the control group. However, the presence of ODPBH did not affect measurements of arterial stiffness in this population.
Abstract (Original Language): 
AMAÇ: Otozomal dominant polikistik böbrek (ODPBH) hastalarında başlıca morbidite ve mortalite nedeni kardiyovasküler (KV) problemlerdir. Bu hasta grubunda böbrek nakli (BN) sonrası KV olaylar hakkında bilgilerimiz sınırlıdır. Bu çalışmada, ODPBH olan ve olmayan BN hastalarında arteriyel elastisite ve KV risk faktörlerinin karşılaştırılması amaçlanmıştır. GEREÇ ve YÖNTEMLER: Koroner anjiografi si normal olan 29 kontrol hastası, ODPBH olan 12 ve olmayan 22 BN alıcısı çalışmaya dahil edildi. Aplanasyon tonometri yöntemi ile tüm katılımcıların arteriyel sertlik ölçümleri yapıldı. BULGULAR: Kontrol grubu ile karşılaştırıldığında tüm BN hastalarının ortalama yaş, boy, kilo, vücut kitle indeksi, bel çevresi ölçümleri, küçük arter elastisite indeksi (KAEİ) ve açlık kan şekeri düzeyleri anlamlı olarak daha düşük bulundu. ODPBH nedeni ile BN olan hastaların ortalama yaşları ve nakil öncesi diyaliz süreleri ve koroner arter hastalığı aile öyküsü oranı ODPBH dışı nedenlerle BN olan hastalara göre anlamlı olarak yüksek bulundu. Her iki BN grubu arasında büyük arter elastisite indeksi (BAEİ) ve KAEİ ölçümlerinde fark saptanmadı. SONUÇ: Arteriyel sertlik ölçümlerinden KAEİ değeri kontrol grubuna göre BN hastalarında daha düşüktür. Ancak ODPBH varlığı bu popülasyonda arteriyel sertlik ölçümlerini etkilememektedir.

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