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NEFROTÎK SENDROM ÎLE SEYREDEN KRONİK LENFOSÎTÎK LÖSEMÎ

CHRONIC LYMPHOCYTIC LEUKEMIA ASSOCIATED WITH NEPHROTIC SYNDROME

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Abstract (2. Language): 
Chronic Lymphocytic Leukemia (CLL) is a hematologic neoplasm characterized by the accumulation mature-appearing lymphocytes in the peripheral blood associated with infiltration of the bone marrow, spleen, lymph nodes and occasionally other organs. Glomerulopathy is a rare complication of CLL The most common clinical presentation of CLL-associated glomerulopathy is the nephrotic syndrome. A 72- year-old woman developed nephrotic syndrome four years after diagnosed Rai Stage- O CLL. Percutaneous renal biopsy showed characteristic features of membranoproliferative glomerulonephritis. At this stage of CLL, treatment with alkylating agents was not recommended. So, we didn't use alkylating agents in our patient. Supportive measures with diuretics, essential aminoacids with ketoanalogues, dipyridamole, acetly salicylic acid were undertaken. Available evidence suggests that nephrotic syndrome associated with CLL is not fortuitous and often related to immun-complex disease.
Abstract (Original Language): 
Kronik lenfositik lösemi (KLL), matürgörünüşdeki lenfositlerin kemik iliği, dalak, lenf nodları, nadiren diğer organlarda infütrasyonu ve periferik kanda birikimi ile karakterize bir hematolojik neoplazmdır. Glomerulopati KLL'nin nadir bir komplikasyonudur. KLL ile bir ar ada olan glomerulopatinin en yaygın klinik görüntüsü nefrotiksendromdur. Rai Stage-0KLL tanısı olan 72 yaşında bir bayan hastada dört yıl sonra nefrotik sendrom gelişmiştir. Per kut an böbrek biyopsisinde membranoproliferatif glomendonefrit saptanmıştır.Bu dönemdeki KLL 'de alkilleyici ajanlarla tedavi önerilmemektedir. Bu nedenle hastamızda alkilleyici ajanları kullanılmamış; diüretik, esansiyel aminoasid-keto analogları, dipridamol, asetil solistlik asit ile destek tedavisi uygulanmıştır. KLL ve glomerulopati birlikteliğinin tesadüfi olmadığı bilinmekte olup, bir immün kompleks hastalığı ile ilintilendirilmektedir.
FULL TEXT (PDF): 
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REFERENCES

References: 

1. Davison AM, Thomson D: Malignancy- Associated
Glomerula
r Disease. Oxfort Textbook of Clinical Nephrology. Davison AM, Cameron JS, Griinfeld JP,
Kerr DNS, Ritz E, Winearls CG (eds) : Oxfort
University Press, New york, 1998: 689-701.
2. Moulin B, Ronco PM, Mougenot B, Francois A, Fillaste
JP, Mignon F: Glomerulonephritis in chronic Iymphoctic leukemia and related B-cell lymphomas. Kidney Int 1992;42: 127-135.
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3. Me Ligeyo SO, Notghi A, Thomson D, Anderson JL: Nephrotic syndrome associated with chonic Iymhocytic leukemia. Nephrol Dial Transplant 1993;8:461-463.
4. Gagliano RG, Costanzi JJ, Beathard GA, Sarles HE, Bell JD: The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome.Report of a case and review of the literature. Am J Med 1978;60 (7): 1026-1031.
5. Keating MJ: The Chronic Leukemias. Bennett JC, Plum F(eds) : Cecil Textbook of Medicine, 20lh edition. WB Saunders Company Philadelphia 1996 : 931-935.
6. Adler SG, Cohen AH, Glassock RJ : Secondary Glomerular Diseases. Brenner BM (ed) : The Kidney, 15th edition. WB Saunders Company Philadelphia 1996 : 1498-1596.
7. Seney FD , Federgreen WR, Stein H, Kasgharian M : A review of nephrotic syndrome associated with chronic lymphocytic leukemia. Arch Intern Med 1986 : 146 (1) :137-141.
8. Lugassy G, Schlesinger M : The complement system in chronic lymphocytic leukemia : a possible role in autoimmune manifestations. Leuk Lymphoma 1996; 21 (5-6): 501-503.

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