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Böbrek Biyopsisi Yapılan Olgularımızın Retrospektif Genel Değerlendirilmesi ve Histopatolojik Alt Gruplarının İncelenmesi

A Retrospective Review of Renal Biopsies and Analysis of Histopathological Subgroups

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2014
DOI: 
10.5262/tndt.2014.1003.03

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
OBJECTIVE: The distribution of renal diseases varies from center to center with respect to race, geographical area and biopsy indications. In this retrospective study we examined renal biopsies performed during a 5-years period. With this study we aimed to determine the spectrum of histological renal diseases in our region with regard to age, gender, clinical indication and renal functions. MATERIAL and METHODS: Two hundred and eighty-nine patients who underwent renal biopsy between January 2008 and December 2012 at Adnan Menderes University, School of Medicine, Department of Internal Medicine, Nephrology Clinic were included in this study. Demographical data, biopsy indications and pathology results were obtained from patients’ files and the computer database retrospectively. Clinical information, chronic diseases, biopsy indications, age, gender, histopathology results, radiological findings and laboratory data were recorded. RESULTS: A total of 289 patients underwent renal biopsy during the 5-year period. The mean age was calculated as 50.8±16.1 (range 18–86) years. 62.3% of the patients were male and the male/ female ratio was calculated as 1.7:1. Nephrotic syndrome was the most common indication for renal biopsy independent from all other variables. Primary glomerulonephritis was the most common renal pathology for all age and gender groups at a ratio of 61.2%. The most common histopathological diagnoses were membranous glomerulonephritis (13.8%), focal segmental glomerulosclerosis (13.1%) and chronic tubulointerstitial nephritis (12.8%). The most common cause of secondary renal disease was amyloidosis (5.2%). Tubulointerstitial nephritis frequency was found to be significantly increased in patients older than 60 years. CONCLUSION: Our study reflects single-center experience. Our findings were in correlation with the findings of other multicenter, long-term studies that include large biopsy series conducted in our country.
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Abstract (Original Language): 
AMAÇ: Renal hastalıkların dağılımı ırk, coğrafi bölge ve biyopsi endikasyonuna göre merkezden merkeze değişmektedir. Bu çalışma ile kliniğimizde beş yıl boyunca yapılan böbrek biyopsileri incelenmiştir. Çalışmanın sonuçları, bölgemizde bulunan böbrek hastalıklarının yaş, cinsiyet, klinik prezentasyon, renal biyopsi endikasyonları ve böbrek fonksiyonlarına göre görülme sıklığının belirlenmesine yardımcı olacaktır. GEREÇ ve YÖNTEMLER: Çalışmaya Adnan Menderes Üniversitesi Tıp Fakültesi İç Hastalıkları Anabilim Dalı Nefroloji Kliniğinde Ocak 2008–Aralık 2012 tarihleri arasında böbrek biyopsisi yapılan 289 hasta alındı. Hastalara ait bilgiler, biyopsi endikasyonları ve patoloji sonuçları hasta dosyaları ve otomasyon sisteminden retrospektif olarak incelenerek öğrenildi. Hastaların klinik özellikleri, mevcut kronik hastalıkları, biyopsi endikasyonları, cinsiyeti, yaşı, histopatolojik sonuçları, radyolojik bulguları ve laboratuvar değerleri kaydedildi. BULGULAR: Çalışmamızda beş yıllık süre boyunca renal biyopsi yapılan hasta sayısı 289’du. Olguların genel yaş ortalaması 50,8±16,1 yıl(18–86 yaş) olarak saptandı ve olguların %62,3’ü erkekti. Erkek/Kadın oranı 1,7:1 olarak bulundu. Tüm değişkinlerden bağımsız olarak en sık biyopsi endikasyonunun nefrotik sendrom olduğu görüldü. Tüm yaş ve cinsiyet gruplarında en sık görülen renal patoloji %61,2 ile primer glomerülonefritlerdi. En sık histopatolojik tanı membranöz glomerülonefrit (%13,8), fokal segmental glomerüloskleroz (%13,1) ve kronik tübülointerstisyel nefrit (%12,8) olarak saptandı. Sistemik hastalıkların tutulumuna bağlı en sık görülen histopatoloji amiloidozdu (%5,2) idi. Altmış yaş üstü hastalarda tübülointerstisyel nefrit oranının belirgin olarak arttığı görüldü. SONUÇ: Çalışma tek merkez deneyimini yansıtmaktadır. Elde edilen bulgular ülkemizde yapılan birçok çalışma gibi literatürde bulunan uzun süreli, çok merkezli ve geniş biyopsi serilerini içeren çalışmalar ile uyumluydu.
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