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Wegener Granülomatosisin Başlangıç Bulgusu Olarak Kranial Sinir Tutulumu: Yanlış Tanı ve Ölümcül Seyreden İki Olgu

Cranial Nerve Injury as an Initial Sign of Wegener Granulomatosis: Misdiagnosis and Fatal Course in Two Cases

Journal Name:

  • Türk Nefroloji, Diyaliz ve Transplantasyon Dergisi

Publication Year:

  • 2014
DOI: 
10.5262/tndt.2014.1002.18

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Highest prevalence of all antineutrophil cytoplasmic antibody associated systemic vasculitides is the Wegener granulomatosis, and it’s typically characterized by a necrotizing granulomatous vasculitis of the respiratory tracts, kidneys, and skin. Neurologic involvement in Wegener granulomatosis ranges from 22% to 54%, but central nervous system involvement is from 2% to 8%. Cranial nerve involvement as an initial sign with concomitant systemic disease is extremely rare. Involvement of one or more cranial nerves is generally a seemingly isolated finding in Wegener granulomatosis. We present WG cases that presented with treatment-resistant cranial nerve involvement and acute fatal pulmonaryrenal syndrome.
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Abstract (Original Language): 
Wegener granülomatosis antinötrofil sitoplazmik antikorlarla ilişkili vaskülitlerde yüksek sıklıkla görülmekle beraber cilt, böbrek ve solunum sisteminin nekrotizan granülomatöz vasküliti ile karekterizedir. Wegener granülomatosiste nörolojik tutulum %22 ile %54 arasında değişmektedir. Buna karşılık santral sinir sistemi tutulumu %2 ile % 8 arasında değişmektedir. Sistemik hastalıkların başlangıç bulgusu olarak kranial sinir tutulumu oldukça nadirdir. Bir ya da daha fazla kranial sinir tutulumu Wegener granülomatosisinde nadiren görülür. Bu olguda kranial sinir tutulumlu, tedaviye dirençli, akut pulmoner-renal sendromlu Wegener granülomatosisi tartışmayı amaçladık.
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  • Turkish

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