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PANSİTOPENİ İLE KENDİNİ GÖSTEREN BİR DİSSEMİNE TÜBERKÜLOZ OLGUSU

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Abstract (2. Language): 
A case of tuberculosis who presented with pancytopenia. Tuberculosis is an infectious disease caused by mycobacterium tuberculosis which is almost exclusively transmitted by contamina-ted respiratory secretions. Pancytopenia is rare in patients with tuberculosis. We report a 64 years-old male patient who was referred to our hospital with refractory anemia despite multip-le transfusions. Laboratory investigation of fhe patient yielded pancytopenia. Multiple granu-lomatous nodules were seen on bone marrow biopsy. Pulmonary tuberculosis was diagnosed with pulmonary infiltrates on computerised tomography of the chest, positive tuberculin test, and with demonstration of acid-resistant bacilli in sputum. The patient received anti-tuberculo-sis therapy. Pancytopenia was partially recovered after 4 months of therapy.
Abstract (Original Language): 
Tüberküloz; mikobakterium tüberkulosis basilinin, çoğu kez solunum yolu ile bulaşması sonucunda ortaya çıkan bir infeksiyon hastalığıdır. Tüberkülozlu hastalarda pansitopeni saptanması nadir bir bulgudur. Bu yazıda çok sayıda kan transfüzyonlarına rağmen devam eden anemi nedeniyle polikliniğimize gönderilen 64 yaşındaki erkek hasta sunulmaktadır. Hastanın laboratuar incelemeleri sonucunda pansitopeni saptandı. Kemik iliği biyopsisinde çok sayıda histiosi-tik granülomatöz nodül görüldü. Akciğer bilgisayarlı tomografisinde infiltrasyon görülmesi, tüberkülin testinin pozitifliği ve balgamda aside dirençli basil saptanması ile tüberküloz tanısı kondu. Hastaya dörtlü antitüberküloz tedavi başlandı. Dört aylık tedavi sonrasında pansitopeni kısmen düzeldi.
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REFERENCES

References: 

1. Alvarez SZ: Hepatobiliary tuberculosis: J. Gastroenterol Hepatol 13:833 (1998).
2. Coburn RJ, England JM, Samson DM, Walfıod DM, Blovvers B, Chanarin I, Levi AJ, Slavin G: Tuberculosis and blood disorders. Br J Haematol 25:793 (1973).
3. Ellman L: Bone marro\v biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am JMed 60:1 (1976).
4. Glasser RM, Walker RI, Herion JC, Chapel Hill NC: The significance of hematologic abnormalities in patients with tuberculosis. Arc Intera Med 125:691 (1970).
5. Katzen H, Spagnolo SV: Bone marrovv necrosis from mi-liary tuberculosis. JAMA 244:2438 (1980).
6. Pease GL: Granulomatous lesions in bone marrovv. Blood 11:720(1956).
7. Robbins SL, Kumar V: Basic Pathology, W.B. Saunders Company, Philadelplıia, 4. Baskı (1987), sayfa: 437.
8. Rosenberg MJ, Rumans LW: Survival of a patient vvith pancytopenia and disseminated coagulation associated vvith miliary tuberculosis. Clıest 73:536 (1978).
9. Tümer Ö: Ekstrapulmoner tüberküloz. Klinik Gelişim 11:626(1998).
10. Weintrub M, Siegman-Ingra Y, Josipov J, Rahmani R, Liıon M: Histiocytic hemophagocytosis in miliary tuberculosis. Arc Intem Med 144:2055 (1984).
11. Wickramasinghe SN. Blood and bone marrovv in Symmers W. st C (ed), Systemic Pathology Vol.2, ed3. London, Churchill Livingstone (1986), sayfa:99.
12. Yaman M. Tüberküloz patogenezi .Klinik Gelişim 11: 593 (1998).

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