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TETRASİKLİNLERİN ANTİENZİMATİK ÖZELLİKLERİNİN PERIODONTAL TEDAVİDEKİ YERİ

ANTIENZYMATIC PROPERTIES OF TETRACYCLINES: POTENTIAL NEW APPROACHES IN THE TREATMENT OF PERIODONTAL DISEASE

Journal Name:

  • İstanbul Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1995

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Tetracyclines and its derivatives are being popular with their antienzymatic properties besides their antimicrobial effects. Chemical modifications of the tetracycline molecule enabled to develop tetracycline analogs capable of inhibiting tissue originated collagenase without exhibiting antimicrobial properties. Similar phenomena have been observed with low dose application of tetracycline. These properties would alter the biochemical tissue distinction cascade leading to more efficient response to conventional periodontal therapy.
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Abstract (Original Language): 
Günümüzde tetrasiklinler ve türevleri antimikrobiyal özelliklerinin yanısıra antienzimatik özellikleri ile de dikkat çekmektedirler. Tetrasİklin molekülünde yapılan kimyasal değişiklikler sayesinde antimikrobiyal özellik taşımayan ancak doku kaynaklı kollajenaz enziminin aktivitesini baskılayabilecek analoglar hazırla-nabilmektedir. Aynı etki tetrasiklinin düşük doz uygulamalarında da gözlenebilmektedir. Bu etki sayesinde periodontal hastalıkta doku yıkımında rol oynayan biyokimyasal mekanizmaların belirli aşamaları kontrol alanda tutularak uygulanan geleneksel periodontal tedavi yaklaşımlarının etkinliği arttırılabilecektir.
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