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EGb 761'in Mannitol ve U74389P ile karşılaştırmalı olarak serebral iskemi üzerine koruyucu rolü

Protective Role of EGb 761 on Cerebral Ischemic Damage, Comparison with Mannitol and U74389p

Journal Name:

  • Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Aim: We designed an experimental study to compare the antiedematous effect of three different kind drugs which were Mannitol, EGb 761 (Ginkgo biloba extract) and U74389p (lazaroid). Materials and Methods: porty rats were assigned into four groups (n=10, for each) as following: Control (saline) group, EGb 761 treatment group, U74389p treatment group, and mannitol treatment group. In all groups, cerebral ischemia was induced by bilateral common carotid artery occlusion. The agents were applied to appropriate groups. The brains were removed and brain water content was determined. Results: The brain water content significantly decreased in EGb 761, mannitol, and U74389p treated groups when compared to control group (p<0.001). On the other hand, the water content was higher in U74389p treated group, comparing with EGb 761 and mannitol groups. Conclusion: These results indicate that EGb 761, U74389p and mannitol are effective treatment agents in the experimental brain ischemia in rats. Among these agents EGb 761 and mannitol showed the best and the same effect
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Abstract (Original Language): 
Amaç: Mannitol, EGb 761 (Ginkgo biloba extract) ve U74389p (lazaroid) 'in antiödematöz etksini karşılaştırmak amacıyla bu çalışma dizayn edildi. Gereç ve yöntem: Herbirinde 10'ar rat olmak üzere 4 grup oluşturuldu. İzotonik NaCl uygulanan kontrol grubu, EGb uygulanan grup, U74389p uygulanan grup ve Mannitol uygulanan grup. Tüm gruplarda bilateral arteria karotis kommunislerin oklüzyonu ile serebral iskemi oluşturuldu. Her gruba ilgili olduğu ilaç uygulandı. Beyinler çıkartılarak beyin su miktarları belirlendi. Bulgular: Beyin su miktarı EGb 761, mannitol, ve U74389p uygulanan gruplarda kontrol grubuna göre anlamlı olarak azaldı (p<0.001). Diğer yandan su miktarı U74389p uygulanan grupta EGb 761 ve mannitol uygulanan gruplara göre daha fazlaydı. Sonuç: EGb 761, U74389p ve mannitol ratlarda oluşturulan deneysel beyin iskemisinde etkili tedavi edici ajanlardır. Bunların içinde EGb 761 ile mannitol en iyi ve aynı etkiyi göstermiştir.
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