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Düşük-Evre Gliomdan Yüksek Evre Glioma Progresyon: Konvansiyonel, Perfüzyon MR ve MR Spektroskopi Bulguları

Progression of Low-Grade Glioma Into High-Grade Glioma: Conventional, Perfusion MR And MR Spectroscopy Findings

Journal Name:

  • Uludağ Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2005

Key Words:

Keywords (Original Language):

Author NameUniversity of Author
Abstract (2. Language): 
Astrocytic tumors have the propensity to change from low-grade to high-grade lesions. Though, it is sometimes difficult to differentiate the two histopathologic entities with conventional MRI (magnetic resonance imaging) findings only. In such circumstances, perfusion MRI with its ability to demonstrate tumoral vascularity indirectly and MR spectroscopy highlighting cellular metabolism can provide additional information about physiology. In this case, we reported the progression of a low-grade tumor into a high-grade lesion with the conventional and perfusion MRI and also MR spectroscopy findings in the light of the literature. In high-grade tumors, apparently high rCBV ratios were depicted as a result of vascular proliferation. Remarkable increase of the cholin peak, moderate increase of the lactate peak and apparent decrease of the n-acetyl aspartate peak were identified at MR spectroscopy.
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Abstract (Original Language): 
Astrositik tümörler çoğunlukla düşük-evreden yüksek evreli lezyona dönüşme eğilimi gösterirler. Konvansiyonel manyetik rezonans (MR) bulguları ile bu iki farklı histopatolojik lezyonun ayrımı bazen güç olabilmektedir. Bu durumda tümöral vaskülariteyi dolaylı gösteren perfüzyon MR ve hücresel metabolizmayı ortaya koyan MR spektroskopi bize fonksiyonel ilave bilgiler verebilmektedir. Biz bu sunuda aynı olguda düşük-evreli astrositomdan yüksek-evreli astrositoma geçişte konvansiyonel, perfüzyon ve spektroskopi MR bulgularını literatür verileriyle birlikte gösterdik. Yüksek-evreli tümörde vasküler proliferasyona bağlı olarak rCBV oranında belirgin yükselme görüldü. MR spektroskopide kolin pikinde ileri derece artma, laktat pikinde orta derecede yükselme ve n-asetil aspartat pikinde ileri derecede azalma izlendi.
FULL TEXT (PDF): 
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  • 2
139-142
  • Turkish

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