Progression of Low-Grade Glioma Into High-Grade Glioma: Conventional, Perfusion MR And MR Spectroscopy Findings
Journal Name:
- Uludağ Üniversitesi Tıp Fakültesi Dergisi
Key Words:
Keywords (Original Language):
Author Name | University of Author |
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Abstract (2. Language):
Astrocytic tumors have the propensity to change from low-grade to high-grade lesions. Though, it is sometimes difficult to differentiate
the two histopathologic entities with conventional MRI (magnetic resonance imaging) findings only. In such circumstances, perfusion
MRI with its ability to demonstrate tumoral vascularity indirectly and MR spectroscopy highlighting cellular metabolism can provide
additional information about physiology. In this case, we reported the progression of a low-grade tumor into a high-grade lesion with the
conventional and perfusion MRI and also MR spectroscopy findings in the light of the literature. In high-grade tumors, apparently high
rCBV ratios were depicted as a result of vascular proliferation. Remarkable increase of the cholin peak, moderate increase of the lactate
peak and apparent decrease of the n-acetyl aspartate peak were identified at MR spectroscopy.
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Abstract (Original Language):
Astrositik tümörler çoğunlukla düşük-evreden yüksek evreli lezyona dönüşme eğilimi gösterirler. Konvansiyonel manyetik rezonans (MR)
bulguları ile bu iki farklı histopatolojik lezyonun ayrımı bazen güç olabilmektedir. Bu durumda tümöral vaskülariteyi dolaylı gösteren
perfüzyon MR ve hücresel metabolizmayı ortaya koyan MR spektroskopi bize fonksiyonel ilave bilgiler verebilmektedir. Biz bu sunuda
aynı olguda düşük-evreli astrositomdan yüksek-evreli astrositoma geçişte konvansiyonel, perfüzyon ve spektroskopi MR bulgularını
literatür verileriyle birlikte gösterdik. Yüksek-evreli tümörde vasküler proliferasyona bağlı olarak rCBV oranında belirgin yükselme
görüldü. MR spektroskopide kolin pikinde ileri derece artma, laktat pikinde orta derecede yükselme ve n-asetil aspartat pikinde ileri
derecede azalma izlendi.
FULL TEXT (PDF):
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