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Ortalama Eritrosit Hacmi Düzeyinin Alkolik Karaciğer Sirozu Tanısındaki Yerinin Belirlenmesi ve Prognoza Etkisinin İrdelenmesi

Determination of the Role of Mean Corpuscular Volume Level on the Diagnosis of Alcoholic Liver Cirrhosis and Investigation of Its Effect on the Prognosis

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2008

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Abstract (2. Language): 
Objectives: In this study, we aimed to determine the relationship between macrocytosis and Alcoholic Liver Cirrhosis (ALC) and its accuracy, sensitivity and specificity rates. Material and Methods: Mean corpuscular volume (MCV) levels of 46 patients diagnosed as having ALC (Group 1) and 51 patients diagnosed as having Hepatitis B cirrhosis and Hepatitis C cirrhosis (Group 2) were compared retrospectively. Results: MCV level determined as 94.6±10.87 in patients in Group 1 was statistically significantly higher than in patients in Group 2 (p<0.001). Macrocytosis was determined in 26 patients (56.52%) in Group 1 but in 3 patients (5.88%) in Group 2. When the cut-off value for MCV in the diagnosis of ALC was taken as 102 fl, its accuracy, sensitivity and specificity rates for the diagnosis were determined as 78%, 93% and 72% respectively. MCV levels of Child class C ALC patients (n=27) were determined statistically significantly higher than MCV levels of Child class A and Child class B ALC patients. Conclusion: We concluded that MCV level is an important variable for the diagnosis of ALC but it is insufficient alone for the diagnosis; macrocytosis frequency increases in these patients and MCV levels increase as the prognosis worsens even without existence of anemia. ©2008, Firat University, Medical Faculty
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Abstract (Original Language): 
Amaç: Alkolik karaciğer sirozunda(AKS) makrositoz sıklığı ve makrositoz ile prognoz arasındaki ilişkinin belirlenerek doğruluk, duyarlılık ve özgüllük değerlerinin tespiti amaçlanmıştır. Gereç ve Yöntem: AKS tanısı olan toplam 46 hasta(grup 1)ile Hepatit B ve C virüslerine bağlı karaciğer sirozu (KS)tanısı olan 51 hastanın(grup 2) ortalama eritrosit hacmi(OEH) düzeyleri retrospektif olarak karşılaştırıldı. Bulgular: Grup 1'de OEH değeri 94.6±10.87 olup, grup 2 hastalardan anlamlı olarak yüksek saptandı(p<0.001).Grup 1'de toplam 26 (%56.52)hastada makrositoz tespit edilirken, grup 2 hastalarda bu oran 3(%5.88)idi. AKS tanısında OEH için cut-off değeri 102 fl olarak alındığında, tanı için doğruluk %78, duyarlılık %93 ve özgüllük %72 olarak saptandı. Child C grubu AKS tanılı hastaların(n=27) OEH'nin Child A ve B AKS tanılı hastalara oranla anlamlı olarak yüksek olduğu tespit edildi. Sonuç: AKS tanısında OEH'nin oldukça önemli olduğu fakat tek başına tanıdaki doğruluğunun yetersiz olduğu, anemi olmaksızın da bu hastalarda makrositoz sıklığının arttığı ve prognoz kötüleştikçe OEH değerinin de arttığı kanısına varıldı ©2008, Fırat Üniversitesi, Tıp Fakültesi
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