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Dağcılarda Yüksek Rakıma Maruz Kalmanın Bazı Serum Akut Faz Proteinleri Üzerine Etkisi

The Effect of High-Altitude Exposure on Serum Levels of Some Acute Phase Proteins in Mountaineers

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The Effect of High-Altitude Exposure on Serum Levels of Some Acute Phase Proteins in Mountaineers Objective: High-altitude exposure is often associated with several clinical conditions such as acute mountain sickness, inflammatory and digestive system disorders. The aim of the present study was to examine the effects of high-altitude on serum levels of some acute phase proteins in the mountaineers with a home residence of height 0 to 800 m. Materials and Methods: This study was carried out in 33 healthy mountaineers (age, 26±8 years; body weight, 70±13 kg; values are means±SD.), who were camping at 2600 m at Palandoken mountain in Erzurum. Fasting blood samples were collected from an antecubital vein on 1* and 7th days of camping onset. Serum C-reactive protein, ceruloplasmin, transferrin, prealbumin, a1-antitrypsine and lipoprotein (a) levels were measured by the nephelometric method. Results: a1-antitrypsine and ceruloplasmin levels were significantly higher (p<0.001, for both), and lipoprotein (a) and prealbumin levels were lower (p<0.001, for both) in serum samples at 7th day when compared to those of 1* day values. C-reactive protein levels were higher in serum at 7th day than onset values, but the increase was not significant (p>0.05). Transferrin levels have not shown a statistically significant difference between groups. Conclusion: Our results show that high-altitude exposure is altering serum levels of some acute phase proteins in mountaineers. ©2008, Firat University, Medical Faculty.
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Abstract (Original Language): 
Amaç: Yüksek rakıma maruz kalma, akut dağ hastalığı, inflamatuar ve sindirim sistemi hastalıkları gibi çeşitli klinik durumlarla sıklıkla ilişkilidir. Bu çalışmanın amacı düşük rakımda yaşayan dağcılarda yüksek rakıma maruz kalmanın bazı serum akut faz proteinleri üzerine olan etkilerini araştırmaktır. Gereç ve Yöntem: Bu çalışma Erzurum Palandöken dağında 2600 m de kamp yapan 33 sağlıklı gönüllü (ortalama yaşları 26±8 yıl; ağırlıkları 70±13 kg) üzerinde yürütüldü. Kampın 1. ve 7. günlerinde açlık venöz kan örnekleri alındı. Serum C-reaktif protein, seruloplazmin, transferrin, prealbumin, al-antitripsin ve lipoprotein (a) düzeyleri nefelometrik metotla ölçüldü. Bulgular: Bazal değerlerle karşılaştırıldığında 7. gün serum örneklerinde ölçülen a1-antitripsin ve seruloplazmin düzeyleri anlamlı şekilde daha yüksek (p<0.001), lipoprotein (a) ve prealbumin düzeyleri daha düşüktü (p<0.001). C-reaktif protein konsantrasyonları 1. gün değerlerine göre 7. günde daha yüksekti fakat bu artış istatistiksel açıdan anlamsızdı. Transferrin düzeylerinde anlamlı bir farklılık gözlenmedi. Sonuç: Dağcılarda yüksek rakımda bazı akut faz proteinlerinin serum konsantrasyonları değişmektedir.
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  • Turkish

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