Buradasınız

Dağcılarda Yüksek Rakıma Maruz Kalmanın Bazı Serum Akut Faz Proteinleri Üzerine Etkisi

The Effect of High-Altitude Exposure on Serum Levels of Some Acute Phase Proteins in Mountaineers

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
The Effect of High-Altitude Exposure on Serum Levels of Some Acute Phase Proteins in Mountaineers Objective: High-altitude exposure is often associated with several clinical conditions such as acute mountain sickness, inflammatory and digestive system disorders. The aim of the present study was to examine the effects of high-altitude on serum levels of some acute phase proteins in the mountaineers with a home residence of height 0 to 800 m. Materials and Methods: This study was carried out in 33 healthy mountaineers (age, 26±8 years; body weight, 70±13 kg; values are means±SD.), who were camping at 2600 m at Palandoken mountain in Erzurum. Fasting blood samples were collected from an antecubital vein on 1* and 7th days of camping onset. Serum C-reactive protein, ceruloplasmin, transferrin, prealbumin, a1-antitrypsine and lipoprotein (a) levels were measured by the nephelometric method. Results: a1-antitrypsine and ceruloplasmin levels were significantly higher (p<0.001, for both), and lipoprotein (a) and prealbumin levels were lower (p<0.001, for both) in serum samples at 7th day when compared to those of 1* day values. C-reactive protein levels were higher in serum at 7th day than onset values, but the increase was not significant (p>0.05). Transferrin levels have not shown a statistically significant difference between groups. Conclusion: Our results show that high-altitude exposure is altering serum levels of some acute phase proteins in mountaineers. ©2008, Firat University, Medical Faculty.
Abstract (Original Language): 
Amaç: Yüksek rakıma maruz kalma, akut dağ hastalığı, inflamatuar ve sindirim sistemi hastalıkları gibi çeşitli klinik durumlarla sıklıkla ilişkilidir. Bu çalışmanın amacı düşük rakımda yaşayan dağcılarda yüksek rakıma maruz kalmanın bazı serum akut faz proteinleri üzerine olan etkilerini araştırmaktır. Gereç ve Yöntem: Bu çalışma Erzurum Palandöken dağında 2600 m de kamp yapan 33 sağlıklı gönüllü (ortalama yaşları 26±8 yıl; ağırlıkları 70±13 kg) üzerinde yürütüldü. Kampın 1. ve 7. günlerinde açlık venöz kan örnekleri alındı. Serum C-reaktif protein, seruloplazmin, transferrin, prealbumin, al-antitripsin ve lipoprotein (a) düzeyleri nefelometrik metotla ölçüldü. Bulgular: Bazal değerlerle karşılaştırıldığında 7. gün serum örneklerinde ölçülen a1-antitripsin ve seruloplazmin düzeyleri anlamlı şekilde daha yüksek (p<0.001), lipoprotein (a) ve prealbumin düzeyleri daha düşüktü (p<0.001). C-reaktif protein konsantrasyonları 1. gün değerlerine göre 7. günde daha yüksekti fakat bu artış istatistiksel açıdan anlamsızdı. Transferrin düzeylerinde anlamlı bir farklılık gözlenmedi. Sonuç: Dağcılarda yüksek rakımda bazı akut faz proteinlerinin serum konsantrasyonları değişmektedir.

REFERENCES

References: 

1. Emery P, Luqmani R. The validity of surrogate markers in rheumatic disease. Br J Rheumatol 1993; 32: 3-8.
2. Lowry SF. Cytokine mediators of immunity and inflammation. Arch Surg 1993; 128: 1235-1241.
3. Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 2005, 6: 1045-1056.
4. Gruys E, Toussaint MJ, Niewold TA et al. Monitoring health by values of acute phase proteins. Acta Histochem 2006; 108:
229-232.
5. Kleessen B, Schroedl W, Stueck M et al. Microbial and immunological responses relative to high-altitude exposure in mountaineers. Med Sci Sports Exerc 2005; 37: 1313-1318.
6. Koruk M, Taysi S, Savas MC et al. Serum levels of acute phase proteins in patients with nonalcoholic steatohepatitis. Turk J Gastroenterol 2003, 14: 12-17.
7. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340: 448-454.
8. Yildirim A, Meral M, Kaynar H, Polat H, Ucar EY.
Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer. Med Sci Monit 2007; 13: CR195-200.
9. Imoberdorf R, Garlick PJ, McNurlan MA et al. Enhanced synthesis of albumin and fibrinogen at high altitude. J Appl
Physiol 2001; 90: 528-537.
10. Kleger GR, Bartsch P, Vock P et al. Evidence against an increase in capillary permeability in subjects exposed to high altitude. J Appl Physiol 1996; 81: 1917-1923.
11. Hood JM, Koep LJ, Peters RL et al. Liver transplantation for advanced liver disease with alpha-1-antitrypsin deficiency. N
Engl J Med 1980; 302: 272-275.
12. Kordula T, Rydel RE, Brigham EF et al. Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes. J Biol Chem 1998, 273: 4112-4118.
13. Venembre P, Boutten A, Seta N et al. Secretion of alpha 1-antitrypsin by alveolar epithelial cells. FEBS Lett 1994; 346:
171-174.
14. Perlmutter DH, Cole FS, Kilbridge P, Rossing TH, Colten HR.
Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages. Proc Natl Acad Sci U S A 1985;
82: 795-799.
15. Hu C, Perlmutter DH. Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by
HNF-1alpha and HNF-4. Am J Physiol 1999; 276: G1181-1194.
16. Hwang SR, Steineckert B, Kohn A, Palkovits M, Hook VY.
Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver. J Biol Chem 1999; 274: 1821-1827.
17. Kalsheker N, Morley S, Morgan K. Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. Biochem Soc Trans 2002; 30: 93-98.
18. Lisowska-Myjak B. AAT as a diagnostic tool. Clin Chim Acta 2005; 352: 1-13.
241
Fırat Tıp Dergisi 2008;13(4): 239-242
Yıldırım ve Ark
19.
Burti
s CA, Ashwood ER. Tietz Klinik Kimyada Temel İlkeler. Aslan D (Çeviri editörü). 5. baskıdan çeviri, Ankara: Palme,
2005.
20. Vij AG, Dutta R, Satija NK. Acclimatization to oxidative stress at high altitude. High Alt Med Biol 2005; 6: 301-310.
21. Beck FK, Rosenthal TC. Prealbumin: a marker for nutritional evaluation. Am Fam Physician 2002; 65: 1575-1578.
22. Surks MI. Metabolism of human serum albumin in man during acute exposure to high altitude (14,100 feet). J Clin Invest 1966; 45: 1442-1451.

Thank you for copying data from http://www.arastirmax.com