Buradasınız

Endemik Guatrlı Hastalarda Tiroid Antikorları

Anti-thyroid antibodies in patients with endemic goitre

Journal Name:

Publication Year:

Keywords (Original Language):

Abstract (2. Language): 
Anti-thyroid antibodies may be present in patients with endemic goitre. We evaluated the levels of antimicrozomal (anti-M), and antithyroglobulin (anti-T) antibodies in 41 patients with endemic goitre and 15 healthy subjects. Anti-M levels were negative in all healthy subjects while 9 (21.95%) of 41 patients had positive titers (G1b; 7.3%, G2; 9.75%, G3; 4.87%). Anti-T levels were within normal range in healthy subjects, and patient groups of G1b, and G2. But it was elevated in patient group G3 (178.85188.44 U/ml). Anti-T values were correlated directly with goitre size (p<0.001). Consequently, thyroid antibodies may be increased with an unknown mechanism in iodine-deficient patients. [Journal of Turgut Özal Medical Center 1998;5(1):30-33]
Abstract (Original Language): 
Endemik guatrda tiroid antikorları artabilmektedir. Bu çalışmada Malatya ilinde yaşayıp, polikliniğimize başvuran ve değişik derecelerde guatrı olan 41 hasta ile 15 sağlıklı kontrol grubunda antimikrozomal (anti-M) ve antitiroglobulin (anti-T) antikorlarının düzeyi araştırıldı. Çalışmamızda anti-M düzeylerini kontrol grubundaki bireylerin tümünde negatif, hasta grubunda ise toplam 41 hastanın 9'unda (%21,95) pozitif olarak saptadık. Bu pozitiflik oranı G1b grubunda %7.3, G2'de %9.75, G3'de ise %4.87 idi. Anti-T düzeyleri ise kontrol grubunda ve hastalarımızın G1b ve G2 gruplarında normal sınırlarda iken G3grubunda normal değerinin yaklaşık iki katına (178,85188,44 U/ml) ulaşıyordu. Anti-T değerleri guatr büyüklüğü ile doğru orantılı artış gösteriyordu (p<0.001). Sonuçlarımız iyot eksikliğinde artış mekanizması tam olarak bilinmese de tiroid antikorlarının artabileceğini göstermektedir. [Turgut Özal Tıp Merkezi Dergisi 1998;5(l):30-33]
30-33

REFERENCES

References: 

1. Fenzi GF, Giusti LF, Lombardi FA, et al. Neuropsychological assesment in school children from an area of moderate iodine deficiency. J Endocrinol Invest 1990;13:427-31.
2.
Koloğl
u S. Türkiye'de Endemik Guatr. Elif Matbaacılık, Ankara 1984:1-64.
3. Chaaouki ML, Maoui R, Benmiloud M. Comperative study of neurological and myxoedematous cretenism associated with severe iodine deficiency. Clin Endocrinol 1988;28:399-408.
4. Eltom M, Hofvander Y, Torelm I. Endemic goitre in the Darfur region (Sudan). Acta Med Scand 1984;215: 467-75.
5.
Med 1991; 23:376-80.
6. Sugawara M, Summer CN, Kobayashi A, et al. Thyroid peroksidase in endemic goiter tissue. J Endocrinol Invest
1990;13:893-99.
7. Burgi U, Scazziga BR, Rosselet PO, et al. Can serum thyroglobulin predict the effect of thyroid hormone therapy on goitre growth? Acta Endocrinol 1988;119:118-24.
8. Roti E, Gardini E, Damato L, et al. Goiter size and thyroid function in an endemic goiter area in Northern Italy. J Clin
Endocrinol Met 1986;63:558-63.
9. Alter CA, Moshang T. Thyroid diagnostic dilemma. Ped Clin
North Am 1991;38:567-77.
10. Fenzi GF, Ceccarelli C, Macchia E, et al. Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area. Clin Endocrinol 1985;23;115-22.
11. Mahoney CP. Differential diagnosis of goiter. Ped Clin North
Am 1987;34: 891-905.
12. Benmiloud M, Chaouki ML, Gutekunst R, Teichert HM,
Wood GW, Dunn JT. Oral iodized oil for correcting iodine deficiency: Optimal dosing and outcome indicator selection. J
Clin Endocrinol 1994; 79:20-24.
13. Steven CB, Andre M, Glen FM, et al. Thyroid autoimmunity in endemic goitre caused by excessive iodine intake. Clin Endocrinol 1989; 31:453-65.

Thank you for copying data from http://www.arastirmax.com