1. Rooman I, Heremans Y, Heimberg H, et al.Modulation
of rat pancreatic acinoductal transdifferentiation and
expression of PDX-1 in vitro.Diabetologia 2000;
43:907-914.
2. Gomez-Dumm CL, Semino MC, Gagliardino JJ. Quantitative
morphological changes in endocrine pancreas
of rats with spontaneous diabetes mellitus.Virchous
Archiv B Cell Pathol 1989; 57:375-381.
3. Waguri M Yamamato K, Miyagawa J, et al. Demostration
of two different processes of β cell regeneration
in a new diabetic mouse model induced by selective
perfusion of alloxan. Diabetes 1997; 46: 1281-1290.
4. Ferrand N, Astesana A, Phan HH, et al. Dynamics
of pancreatic cell growth and differentiation during
diabetes reversion in STZ treated newborn rats .Am J
Physiol 1995; 269 (Cell Physiol 38): 1250-1264.
5. Portha B, Blondel O, Serradas P, et al. The rat models
of non-insülin dependent diabetes induced by neonatal
streptozotocin. Diabetes Metabolisme. 1989;15:61-75.
6. Movassat J, Saulnier C, Portha B. Insülin administration
enhances growth of the B cell mass in streptozotocintreated
newborn rats Diabetes 1997;46: 1445-1452.
7. Oztürk M, Bolkent S, Kaya Dagistanli F, et al. Effects
of 5-aminoimidazole-4-carboxamide riboside on
pancreas in neonatal streptozotocin diabetic rats. Acta
Diabetol 2006; 43:61-65.
8. Oztürk M, Tunçdemir M, Bolkent S, et al. Effect of
AICA-riboside treatment on aortic alteration in neonatal
STZ-induced diabetic rat. In: Angiogenesis, Models,
Modulators and Clinical Applications. Plenum Press,
New York and London. 1998: pp541-542.
9. Kaya F. Yenidoğan streptozotocin diabetik sıçanlarda
somatostatin analoğu ve kalsiyum kanal blokerinin
apoptoz üzerine etkileri. İ.Ü. Sağlık Bilimleri Enstitüsü
Tıbbi Biyoloji Anabilim Dalı. Bitmiş Yüksek Lisans Tezi;
1998.
10. Risbud MV, Bhonde RR. Models of pancreatic regeneration
in diabetes. Diabetes Res Clin Pract 2002;
58: 155-165.
11. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy
in the rat and subsequent defect in glucose-induced
insulin release. J Clin Invest 1983; 71: 1544-
1553.
12. Wang RN, Kloppel G, Bouwens L. Duct- to islet-cell
differentiation and islet growth in the pancreas of ductligated
adult rats. Diabetologia 1995; 38:1405-1411.
13. Wang RN, Bouwens L, Kloppel G. Beta-cell proliferation
in normal and streptozotocin-treated newborn
rats: site, dynamics and capacity. Diabetologia 1994;
37:1088-1096.
14. Song KH, Ko SH, Ahn YB, et al. In vitro transdifferentiation
of adult pancreatic acinar cells into insulinexpressing
cells. Biochem Biophys Res Commun 2004;
316:1094-1100.
15. Bouwens L, Wang RN, De Blay E, et al. Cytokeratins
as markers of ductal cell differentiation and islet neogenesis
in the neonatal rat pancreas. Diabetes 1994;
43: 1279-1283.
16. Bouwens L. Transdifferentiation versus stem cell hypothesis
for the regeneration of islet beta-cells in the
pancreas. Microsc Res Tech 1998; 43:332-336.
17. Zangen DH, Bonner Weir S, Lee CH, et al. Reduced
insülin, GLUT2, and IDX-1 in beta cells after partial
pancreatectomy. Diabetes 1997; 46:258-264.
18. Petropavlovskaia M, Rosenberg L. Identification and
characterization of small cells in the adult pancreas:
potential progenitor cells? Cell Tissue Res 2002; 310:
51-58.
19. McKinnon CM, Docherty K. Pancreatic duodenal homeobox-
1, PDX-1, a major regulator of beta cell identity
and function. Diabetologia 2001; 44: 1203-
1214.
20. Fernandes A, King LC, Guz Y, et al. Teitelman G.Differentiation
of new insulin-producing cells is induced
by injury in adult pancreatic islets. Endocrinology
1997; 138: 1750-1762.
21. Wiedenmann B, Franke WW, Kuhn C, et al. Synaptophysin:
a marker protein for neuroendocrine cells
and neoplasms. Proc Natl Acad Sci USA. 1986, 83(10):
3500-3504.
22. Lukinius A, Stridsberg M, Wilander E. Cellular expression
and specific intragranular localization of chromogranin
A, chromogranin B, and synaptophysin during
ontogeny of pancreatic islet cells: an ultrastructural
study. Pancreas 2003; 27:38-46.
23. Tezel GG, Tezel E. Nöroendokrin-dışı tümörlerde nöroendokrin
diferansiasyon ve nöroendokrin diferansiasyonun
moleküler biyolojisi. Erişim: 26.03.06 http://
www.medinfo.hacettepe.edu.tr/tebad/dergi/
doc/2005_1/19-27.doc
24. Wali RK, Dudeja PK, Bolt MJG, et al. Correction of
abnormal small intestinal cytosolic protein kinase C
activity in streptozotocin-induces diabetes by insulin
theraphy. Biochem J 1990; 272: 653-658.
25. Bolkent S, Yılmazer S, Oztürk M. Combined non-radioactive
detection of peptide hormones and their
mRNAs in stomach somatostatin cells. Regul Pept
1995; 22: 17-21.
26. Thyssen S, Arany E, Hill DJ. Ontogeny of regeneration
of beta-cells in the neonatal rat after treatment with
streptozotocin. Endocrinology 2006; 147: 2346-
2345.
27. Cantenys D, Portha B, Dutrillaux MC, et al. Histogenesis
of the endocrine pancreas in newborn rats after
destruction by streptozotocin. An immunocytochemical
study.Virchows Arch B Cell Pathol Incl Mol
Pathol 1981; 35: 109-122.
28. Dutriloux MC, Portha B, Roze C, et al. Ultrastructural
study of pancreatic β - cell regeneration in the newborn
rats after destruction by streptozotocin. Virchows
Archiv (Cell Pathol) 1982; 39: 173-185.
29. Wang RN, Bouwens L, Kloppel G. Beta-cell growth
in adolescent and adult rats treated with streptozotocin
during the neonatal period. Diabetologia.1996;
39: 548-547.
30. Jain K, Logothetopoulos J. Proinsulin biosynthesis by
pancreatic islets of the rat and the study of alloxan
cytotoxicity in vitro. Biochim Biophys Acta 1976;
435: 145-151.
31. Maldonato A, Trueheart PA, Renold AE, et al. Effects
of streptozotocin in vitro on proinsulin biosynthesis,
insulin release and ATP content of isolated rat islets
of Langerhans. Diabetologia 1976; 12: 471-481.
32. Bonner-Weir S, Trent DF, Honey RN, et al. Responses
of neonatal rat islets to streptozotocin: limited B-cell
regeneration and hyperglycemia. Diabetes 1981; 30:
64-69.
33. Li L, Yi Z, Seno M, et al. Activin A and betacellulin:
effect on regeneration of pancreatic beta-cells in neonatal
streptozotocin-treated rats. Diabetes 2004,53:
608-615.
34. Rosenberg L. In vivo cell transformation: neogenesis
of beta cells from pancreatic ductal cells. Cell Transplant
1995; 4: 371-383.
35. Rosenberg L, Brown RA, Duguid WP. A new approach
to the induction of duct epithelial hyperplasia and
137
Cerrahpafla T›p Derg 2007; 38: 127 - 138
nesidioblastosis by cellophane wrapping of the hamster
pancreas. J Surg Res 1983; 35: 63-72.
36. Cornelius JG, Tchernev V, Kao KJ, et al. In vitro-generation
of islets in long-term cultures of pluripotent
stem cells from adult mouse pancreas. Horm Metab
Res 1997; 29: 271-277.
37. Mashima H, Ohnishi H, Wakabayashi K, et al. Betacellulin
and activin A coordinately convert amylasesecreting
pancreatic AR42J cells into insulin-secreting
cells. J Clin Invest 1996; 97: 1647-1654.
38. Gu D, Arnush M, Sarvetnick N. Endocrine/exocrine
intermediate cells in streptozotocin -treated Ins-IFNgamma
transgenic mice. Pancreas 1997; 15: 246-
250.
39. Movassat J, Saulnier C, Portha B. Insulin administration
enhances growth of the beta-cell mass in streptozotocintreated
newborn rats. Diabetes 1997; 46: 1445-1452.
40. Suzuki T, Kadoya Y, Sato Y, et al. The expression of
pancreatic endocrine markers in centroacinar cells
of the normal and regenerating rat pancreas: their
possible transformation to endocrine cells. Arch Histol
Cytol. 2003; 66: 347-358.
41. Permutt MA, Kipnis DM. Insulin biosynthesis. I. On
the mechanism of glucose stimulation. J Biol Chem
1972; 247: 1194-1199.
42. Ashcroft SJ, Bunce J, Lowry M, et al. The effect of
sugars on (pro)insulin biosynthesis. Biochem J 1978;
174: 517-526.
43. German M, Ashcroft S, Docherty K, et al. The insulin
gene promoter. A simplified nomenclature. Diabetes
1995; 44: 1002-1004.
44. Ahlgren U, Jonsson J, Edlund H. The morphogenesis
of the pancreatic mesenchyme is uncoupled from
that of the pancreatic epithelium in IPF1/PDX1-deficient
mice. Development 1996; 122: 1409-1416.
45. Ahlgren U, Jonsson J, Jonsson L, et al. Beta-cell-specific
inactivation of the mouse Ipf1/Pdx1 gene results
in loss of the beta-cell phenotype and maturity onset
diabetes. Genes Dev 1998; 15:1763-1768.
46. Stoffers DA, Zinkin NT, Stanojevic V, et al. Pancreatic
agenesis attributable to a single nucleotide deletion
in the human IPF1 gene coding sequence. Nat Genet
1997; 15: 106-110.
47. Arantes VC, Teixeira VP, Reis MA, et al. Expression of
PDX-1 is reduced in pancreatic islets from pups of
rat dams fed a low protein diet during gestation and
lactation. J Nutr 2002; 132: 3030-3035.
48. Elrick LJ, Docherty K. Phosphorylation-dependent
nucleocytoplasmic shuttling of pancreatic düodenal
homeobox-1. Diabetes 2001; 50: 2244-2252.
49. Wang Y, Egan JM, Raygada M, et al. Glucagon-like
peptide-1 affects gene transcription and messenger
ribonucleic acid stability of components of the insulin
secretory system in RIN 1046-38 cells. Endocrinology
1995; 136: 4910-4917.
50. Melloul D. Transcription factors in islet development
and physiology: role of PDX-1 in beta-cell function.
Ann N Y Acad Sci 2004; 1014: 28-37.
51. Hui H, Perfetti R. Pancreas duodenum homeobox-1
regulates pancreas development during embryogenesis
and islet cell function in adulthood. Eur J Endocrinol
2002; 146: 129-141.
52. Bonner-Weir S. Perspective: Postnatal pancreatic beta
cell growth. Endocrinology 2000; 141: 1926-1929.
Thank you for copying data from http://www.arastirmax.com