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Kronik Böbrek Hastalarında ve Diyaliz Hastalarında 25 (OH) Vitamin D

25 (OH) Vitamin D in Patients with Chronic Kidney Disease and Dialysis Patients

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DOI 10.5262/tndt.2012.1003.02

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Abstract (2. Language): 
In addition to its role on calcium homeostasis, vitamin D exhibits local (paracrine) effects on cell proliferation differentiation and immune function. Most cells in the body express Vitamin D receptors and 1α-hydroxylase, thereby permitting local production of 1,25 dihydroxycholecalciferol, which has therapeutic implications (paracrine effects). Studies have shown that chronic vitamin D deficiency may have serious adverse consequences such as increased risk of hypertension, multiple sclerosis, rheumatoid arthritis, cancer of the colon, prostate, breast, ovary, and type 1 diabetes. However, information about the effect of vitamin D supplementation and replacement, and cardiometabolic outcomes is very limited. Studies on Vitamin D replacement in patients with chronic kidney disease and dialysis patients are needed.
Abstract (Original Language): 
Vitamin D’nin kalsiyum hemostazının yanı sıra, hücre çoğalması, farklılaşması ve immün sistem üzerine lokal etkileri vardır. Vücutta birçok hücrede vitamin D reseptörü ve 1α hidroksilaz mevcuttur, dolayısıyla 1,25 dihidroksikolekalsiferol lokal sentezlenerek etki gösterir (parakrin etki). Yapılan çalışmalarda kronik vitamin D eksikliğinin hipertansiyon, multiple skleroz, romatoid artrit, kolon, prostat, meme, over kanseri ve tip 1 diyabet riskini arttırdığı gösterilmiştir. Ancak vitamin D yerine koyulmasının ve ilavesinin etkileri ve kardiyometabolik duruma etkileri hakkındaki bilgiler sınırlıdır. Kronik böbrek hastaları ve diyaliz hastalarında vitamin D (kolekalsiferol) yerine koyulmasının etkilerini inceleyen çalışmalara gerek vardır.



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